Importance of the Spleen to Survival from P falciparum
Abstract: P falciparum infections carry a considerable mortality risk, but the nature of the ‘immunity’ gained from infection experience is uncertain. Although anaemia may contribute some protection against mortality, the function of the spleen appears critical to controlling P falciparum parasitemia and increasing survival. Melanesian reports suggest that survival advantages of P vivax infections and […]
Antimalarial Drug Supply Issues during the Second World War
Abstract Malaria was a major cause of casualties during World War II in the Southwest Pacific, and drug supply issues were acute strategic concerns. The capture of the cinchona plantations of Indonesia by the Japanese Imperial Army and the lack of manufacturing capacity for synthetic substitutes were significant logistical constraints that limited Allied combat operations […]